Assuming your bike still has the standard 18 tooth front (gearbox) sprocket, ime initially only change that to 19 teeth, leave the rear sprocket as 46 teeth until you try riding the bike. Only if it is then still too buzzy at 65, but still has plenty of acceleration, consider changing the rear sprocket to 43 teeth.
19 teeth gearbox with 46 teeth rear might require an extra pair of links in any new chain. New chain, it is cheaper to start with too many links, removing pairs with a chain breaker if necessary, than buy too short and have to buy another new longer chain.
19 teeth gearbox sprocket is the largest that will fit through the primary access without modifying it, 20 teeth also robs a 500 of too much acceleration. Because the 500 does not have the conical rear hub, 43 and 46 teeth rear sprockets are the only off the shelf options available afaik.